My research focuses on identifying novel diagnostic biomarkers for complex diseases by integrating and analyzing high-throughput "omics" data that implicates disease-disturbed functions in DNAs, RNAs, proteins, and metabolites. I aim to assemble a multi-level network interlinked with common "disease modules" across multiple tissues, genotypes, and species. Collaborating closely with experimental groups, I merged first-hand experimental data collected with cutting-edge technologies and state-of-the-art computational techniques. As a result, the insights provided by my clinical systems biology research can impose a "top-down" systematic perspective on current understanding of biological processes, and potentially revise traditional therapies for complex diseases, such as Post-traumatic Stress Disorder (PTSD), cancer, prion diseases, and circadian rhythm disorders.