Ruoting Yang

Journey to 
Systems Biology 

Education


Education

Ph.D. in Electrical and Systems Engineering,
Washington University in St. Loui
s, MO, USA| July, 2008

M.S. in Electric Engineering
Washington University in St. Louis, MO, USA | May, 2005

M.S. in Control Theory
Academy of Mathematics & Systems Science, Beijing, China | May, 2003

  B.E. in Automation
Xiamen University, Xiamen, China | May, 2000

Research Interests

Clinical systems biology, biomarker identification, bioinformatics, computational models, control theory,
  biomimetic robotics

Research Experience

PostdoctoralResearch Fellow                                                    08/2009-Present  

University of California, Santa Barbara

Project:  Biomarkers studies for Post-Traumatic Stress Disorder (PTSD)

Genetic biomarker identification and disease network construction; "Bottom-up" modeling in a control engineering framework;"Omics" data analysis, integration, and visualization

Postdoctoral Research Associate                                             08/2008-07/2009   

University of Tennessee, Knoxville

Project:  Modeling biological systems and biomimetic robotics

Intracellular control of S cerevisiae; Bio-mimetic flytrap robot; Immune system models;  Immuno-inspired multi-agent robots 

Doctoral Research                                                                     08/2003-07/2008

Washington University in St. Louis

Data-driven two degree of freedom control for drug delivery

Teaching Experiences 

Instructor, Systems Engineering Lab, WUSTL, Fall 2006, Rating 8.0/9
Instructor, Robotics Lab, WUSTL, Spring 2007, Rating 8.1/9

Synergistic Activities

Member of Program Committee: IEEE Conference on Robotics & Biomimetics,             2010/2011

Session Chair: Bioinformatics & biomaterials, 12th UC Bioengineering symposium, Santa Barbara, 2011; Autonomous vehicles, IEEE/RSJ Conference on Intelligent Robots & Systems, St. Louis, 2009

Journal Reviewer: IEEE Transactions on Neural Networks, IEEE Transactions on Automation Sciences and Engineering, IEEE Transactions on Circuits and Systems I, Gene Regulation and Systems Biology, Journal of Systems Engineering, Journal of Systems Science and Complexity, IET Control Theory and Applications

Peer-review Conferences Reviewer: ROBIO10&11, CDC10, ACC10,11&12, CASE09, DSCC09, IMECE09, IROS09&10, MSC10, ICRA08, IFAC08

Awards

Best Automation Paper Award Finalist and Travel Award

IEEE Conference on Robotics & Automation, Pasadena, CA, USA, May, 2008      

Publications

JOURNAL ARTICLES

  1. R Yang, BJ Daigle Jr, SY Muhim, R Hammamieh, M Jett, LR Petzold, FJ Doyle III, Core Modular Blood and Brain Biomarkers in Social Defeat Mouse Model for Post Traumatic Stress Disorder, BMC Systems Biology, Minor revision, 2013.
  2. R Hammamieh, SY Muhim, R Yang, M Jett, Systems biology of post-traumatic stress disorder: characterization of pathways and networks involved in the development of PTSD, European Journal of Psychotraumatology, 3(1), 2012.
  3. X Liu, Y Shen, R Yang, S Zou, X Ji, L Shi, Y Zhang, R Li, Y Tang, D Liu, L Xiao, S Li, X Zheng, S Li, J Fan, G. D. Stucky, Inkjet printing assisted synthesis of multicomponent mesoporous metal oxides for ultrafast catalyst exploration, Nano Letter, 12(11), 2012. 
  4. R Yang, BJ Daigle Jr, LR Petzold, FJ Doyle III, Core Module BiomarkerIdentification with Network Exploration for Breast Cancer MetastasisBMC Bioinformatics, 13 (12), 2012. source codedataset 1; dataset 2; dataset 3; Annotation
  5. R Yang, SC Lenaghan, and M Zhang, External Control of the GAL Network in S. cerevisiae: A View from Control Theory, PLoS One, 6(4): e19353, 2011.
  6. R Yang, S Bewick, M Zhang, and WR Hamel, Adaptive Immune System TH1/TH2 Differentiation Mechanism Inspired Perimeter Patrol Control Strategy, IEEE Trans Contr Syst Tech, 19 (2):407-415, 2011.
  7. S Bewick, J Wu, SC Lenaghan, R Yang, M Zhang, and W.R. Hamel, The R5 to X4 Coreceptor Switch: A Dead-end Path or a Strategic Maneuver? Lessons from a Game Theoretic Analysis, Bull Math Biol, 73(10): 2339-2356, 2011.
  8. R Yang, SC Lenaghan, L Xia, and M Zhang, A Mathematical Model on the Closing and Opening Mechanism for Venus Flytrap, Plant Signal Behav, 5(8): 968-978, 2010.
  9. R Yang, M Zhang, and TJ Tarn, Data-driven Feedforward Control of Electroporation Mediated Gene Delivery in Gene Therapy, IEEE Trans Contr Syst Tech, 18(4): 935-943, 2010.
  10. X Zhao, R Yang, M Zhang, and H Xia, A Computational Approach for Understanding Immune Response to Multiple Epitopes based on Optimal Control Formulation, Commun Nonlinear Sci Numer Simul, 15(12): 4209-4218, 2010.
  11. X Zhao, M Zhang, and R Yang, Control of Pore Radius Regulation for Electroporation-based Drug Delivery, Commun Nonlinear Sci Numer Simul, 15(5): 1400-1407, 2010.
  12. S Bewick, R Yang, and M Zhang, The Danger is Growing!  A New Paradigm for Immune System Activation and Peripheral Tolerance, PLoS One, 4(12): e8112, 2009.
  13. S Bewick, R Yang and M Zhang, Complex Mathematical Models of Biology at the Nanoscale, WIREs Nanomed Nanobiotechno, 1(6): 650-659, 2009.
  14. 11. R Yang, Y Hong, H Qin, and G Chen, Anticontrol of chaos for dynamic systems in p-normal form: A homogeneity-based approach, Chaos Soliton Fract, 25(3), 687-697, 2005. 

SUBMITTED/IN PREPARATION JOURNAL ARTICLES

  1. R Yang, BJ Daigle Jr, LR Petzold, FJ Doyle III, Pathflower: A Tool of Functional Analysis and Visualization for Genetic Data, To be submitted to Bioinformatics.
  2. R Yang, K Sriram, and FJ Doyle III, Control Model for Fear Conditioning Associated with Post-Traumatic Stress Disorder (PTSD), In preparation. 

BOOK CHAPTERS

  1. R Yang, SC Lenaghan, and M Zhang, Mathematical Modeling, Dynamics Analysis and Control of Carnivorous Plants, book chapter in Plant Electrophysiology, Springer, Under review, 2011.
  2. R Yang, M Zhang, and TJ Tarn, Control Mechanisms for Life Science Automation, book chapter in Life Science Automation: Fundamentals and Applications, Artech House Publishers, 2007. 

REFEREED PROCEEDINGS

  1. R Yang, K Sriram, and FJ Doyle III, Control Circuitry for Fear Conditioning Associated with Post-Traumatic Stress Disorder (PTSD),  Proceedings of the IEEE Conference on Decision and Control, Atlanta, GA, 2010.
  2. J Wu, S Bewick, R Yang, SC Lenaghan, and M Zhang, Evolutionary Game Theoretical Approach for Understanding CCR5 to CXCR4 Coreceptor Switch, Proceedings of the American Control Conference, Baltimore, MD, 2010.
  3. R Yang, SC Lenaghan, L Xia, and M Zhang, Sensing and Closing Mechanism for Venus Flytrap: Theoretical and Experimental Studies, Proceedings of the IEEE Nanotechnology Materials and Devices Conference, Traverse City, MI, 2009.
  4. S Bewick, R Yang, and M Zhang, Embedding Evolutionary Game Theory into an Optimal Control Framework for Drug Dosage Design, Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Minneapolis, MN, 2009.
  5. R Yang, S Bewick, M Zhang, WR Hamel, and TJ Tarn, Adaptive Immune System Inspired Perimeter Patrol Control Strategy, Proceedings of the  IEEE/RSJ International Conference on Intelligent Robots and Systems, St. Louis, MO, 2009.
  6. S Bewick, R Yang, M Zhang, and WR Hamel, Passive vs. aggressive strategies: A game theoretic analysis of military defense, Proceedings of the 2009 IEEE/RSJ International Conference on Intelligent Robots and Systems, St. Louis, MO, 2009.
  7. R Yang, S Bewick, M Zhang, Optimal Control in Immunodominance, Proceedings of the first Annual ORNL Biomedical Science and Engineering Conference, Knoxville, TN, 2009.
  8. R Yang, TJ Tarn, and M Zhang, Data-driven Feedforward Design for Electroporation Mediated Gene Delivery, Proceedings of the IEEE Conference on Nanotechnology, Genoa, Italy, 2009.
  9. R Yang, TJ Tarn, and M Zhang, Event-based Two Degree-of-freedom Control for Micro-/Nanoscale Systems based on Differential Flatness, Proceedings of the IEEE International Conference on Robotics & Automation, Pasadena, CA, 2008.
  10. R Yang, TJ Tarn, and M Zhang, Event-based Feedforward Control of a Drug Delivery System for Diabetes Cares, Proceedings of the International Federation of Automatic Control, Seoul, Korea, 2008.
  11. T Hogg, M Zhang, and R Yang, Modeling and Analysis of DNA Hybridization Dynamics at Microarray Surface in Moving Fluid, Proceedings of the IEEE International Conference on Robotics & Automation, Pasadena, CA, 2008.
  12. R Yang, M Zhang, and TJ Tarn, Adaptive Backstepping Control of a Micro-needle Integrated Piezoelectric Micro-pump for Diabetes Care, Proceedings of the IEEE Conference on Nanotechnology, Hong Kong, 2007.
  13. R Yang, M Zhang, and TJ Tarn, Dynamics Modeling and Control of a Micro-needle Integrated Piezoelectric Micro-pump for Diabetes Care, Proceedings of the IEEE Conference on Nanotechnology, Cincinnati, OH, 2006. 

CONFERENCES (Presenter underlined)

  1. R Yang, BJ Daigle Jr, LR Petzold, FJ Doyle III, Identification for Robust Pathway Biomarkers, Q-bio Conference, Santa Fe, New Mexico, 2011. Poster.
  2. R Yang, BJ Daigle Jr, LR Petzold, FJ Doyle III, Pathway-based Biomarker Identification for Post-Traumatic Stress Disorder (PTSD), UC Bioengineering symposium, Santa Barbara, CA, 2011. Poster.
  3. R Yang, BJ Daigle Jr, LR Petzold, FJ Doyle III, Biomarker Discovery for Post-Traumatic Stress Disorder (PTSD), Engineering Insights, UCSB, CA, 2011. Poster.
  4. R Yang, M Zhang, and TJ Tarn, Data-driven two degree-of-freedom control for a micropump and microneedle integrated device for diabetes care, The Sixteenth International Symposium on Artificial Life and Robotics, Beppu, Japan 2011. Plenary Talk.
  5. R Yang, BJ Daigle Jr, LR Petzold, FJ Doyle III, Biomarker Identification for Post-Traumatic Stress Disorder (PTSD), SoCal SysBio Conference, Irvine, CA, 2010. Poster.

Professional Affiliations

IEEE Member since 2007

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